Pixelmator 2.0

Pros:
A wealth of tools and features, Clean and fluid interface, Robust brush support (Photoshop brush compatible), Illustrator-style vector pen and shape tools, Support for OS X Lion Auto Save and Versions., Export to Mail, iPhoto, and other apps/services, Fresh filters and clever filter interface

Cons:
No adjustment or fill layers, Vector shapes cannot be filled with gradients, Palettes do not snap/dock together